McDonald 2024 Checker

References

Montalban X, Lebrun-Frenay C, Oh J, et al. Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Lancet Neurol. 2025;24(10):850-865. PubMed
Barkhof F, Reich DS, Oh J, et al. 2024 MAGNIMS-CMSC-NAIMS consensus recommendations on the use of MRI for the diagnosis of multiple sclerosis. Lancet Neurol. 2025;24(10):866-879. PubMed
Saidha S, Green AJ, Leocani L, et al. The use of optical coherence tomography and visual evoked potentials in the 2024 McDonald diagnostic criteria for multiple sclerosis. Lancet Neurol. 2025;24(10):880-892. PubMed
Deisenhammer F, Hegen H, Arrambide G, et al. Positive cerebrospinal fluid in the 2024 McDonald criteria for multiple sclerosis. EBioMedicine. 2025;120:105905. PubMed

Presentation

Structured entry based on the project flow discussed in the prior sessions.

Age

Better explanations excluded

Presentation type

Symptoms and signs characteristic of MS

Progression for 12 months or longer from symptom onset

Relevant vascular comorbidity

The 5 anatomical locations used in the 2024 framework.

Optic nerve Juxtacortical / cortical Periventricular Infratentorial Spinal cord

Two or more spinal cord lesions DIT present by MRI activity (gadolinium-positive lesions or new T2 lesions)

Shown because the optic nerve was not already selected as an involved site.

OCT asymmetry >= 6 um pRNFL and/or >4 um GCIPL VEP positive for optic nerve involvement

Interpretive CSF inputs used to derive a positive CSF result.

OCB: pattern 2 or 3 kFLC >= 6.1

Specificity-supporting MRI markers entered as already interpreted results.

CVS positive (select-6 rule) Less than 10 lesions, with most lesions CVS-positive

At least 1 PRL